Side Effects of Lidocaine Brookline MA

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Bournewood Hospital
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300 South Street
Chestnut Hill, MA
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Brighton Family Practice
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Brighton, MA
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Granada House Inc
(617) 254-2923
70 Adamson Street
Allston, MA
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Substance abuse , Halfway house
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Residential long-term treatment (more than 30 days)
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Whittier Street Health Center
(617) 427-1000
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Roxbury, MA
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Substance abuse , Buprenorphine Services
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Persons with co-occurring mental and substance abuse disorders, Men
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Latin American Health Institute
(617) 350-6900
95 Berkeley Street
Boston, MA
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Substance abuse
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Persons with co-occurring mental and substance abuse disorders, Men, DUI/DWI offenders
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Fenway Community Health Center
(617) 267-0900
7 Haviland Street
Boston, MA
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Substance abuse , Detoxification
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Childrens Hospital Pediatric Assoc
(617) 355-2727
300 Longwood Avenue
Boston, MA
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Tecumseh House
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107 Fisher Avenue
Roxbury, MA
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Addiction Treatment Center of
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77 Warren Street
Brighton, MA
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Substance abuse , Methadone Maintenance, Methadone Detoxification
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Outpatient
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Persons with co-occurring mental and substance abuse disorders, Persons with HIV/AIDS, Gays and Lesbians, Pregnant/postpartum women, Women
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ASL or other assistance for hearing impaired, French, Spanish

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Victory Programs Inc
(617) 522-2936
170 Morton Street
Jamaica Plain, MA
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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