Side Effects of Lidocaine Allston MA

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Granada House Inc
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Allston, MA
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Substance abuse , Halfway house
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Brighton Family Practice
(617) 254-8500
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Brighton, MA
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Prevention and Recovery Center
(617) 499-5051x4047
330 Mount Auburn Street
Cambridge, MA
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Fenway Community Health Center
(617) 267-0900
7 Haviland Street
Boston, MA
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Substance abuse , Detoxification
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North Charles Institute
(617) 661-5700
260 Beacon Street
Somerville, MA
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Addiction Treatment Center of
(617) 254-1271
77 Warren Street
Brighton, MA
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Concilio Hispano Inc
(617) 661-9406
105 Windsor Street
Cambridge, MA
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Catholic Charities
(617) 332-9905
295 Adams Street (Rear)
Newton, MA
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Substance abuse , Buprenorphine Services
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Riverside Outpatient Center
(617) 969-4925
64 Eldredge Street
Newton, MA
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(800) 529-5077
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Cambridge Health Alliance
(617) 591-6051
26 Central Street
Somerville, MA
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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