Side Effects of Lidocaine Fredericksburg VA

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Rappahannock Area Comm Services Board
(540) 373-3223x3050
600 Jackson Street
Fredericksburg, VA
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(540) 373-6876
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A Womans Place
(540) 891-3136
2016 Lafeyette Boulevard
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(540) 582-3980x3015
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Spotsylvania, VA
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Clinch Valley Treatment Center
(276) 963-3554
111 Town Hollow Road
Cedar Bluff, VA
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Substance abuse , Detoxification, Methadone Maintenance, Methadone Detoxification, Buprenorphine Services
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(540) 343-4261
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Roanoke, VA
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Women, Residential beds for clients' children

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(540) 371-3059
514 Wolfe Street
Fredericksburg, VA
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Rappahannock Area Comm Services Board
(540) 659-2725
15 Hope Road
Stafford, VA
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Outpatient
Special Programs/Groups
Adolescents

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(703) 784-3502
MCCS (Attn: CSACC)
MCB Quantico, VA
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Manassas, VA
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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