Side Effects of Lidocaine Cape May Court House NJ

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Nancy C Craft Counseling Services
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Cape May Court House, NJ
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Family Addiction Treatment Center
(609) 601-8611
408 Bethel Road
Somers Point, NJ
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Substance abuse , Detoxification, Methadone Maintenance, Methadone Detoxification, Buprenorphine Services
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Damon House Inc
(732) 828-6002
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New Brunswick, NJ
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Professional Counseling Associates
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Oradell, NJ
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(609) 465-2233
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(609) 653-0993
505 New Road
Somers Point, NJ
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Lyons, NJ
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Carrier Clinic
(908) 281-1000x1331
252 County Route 601
Belle Mead, NJ
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(609) 267-7000x2148
650 Rancocas Road
Westampton, NJ
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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