Side Effects of Lidocaine Boston MA

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Boston Public Health Commission
(617) 534-4212
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Boston, MA
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CAB Boston Treatment Center
(617) 247-1001
784 Massachusetts Avenue
Boston, MA
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Latin American Health Institute
(617) 350-6900
95 Berkeley Street
Boston, MA
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Persons with co-occurring mental and substance abuse disorders, Men, DUI/DWI offenders
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Bay Cove Human Services
(617) 371-3030
66 Canal Street
Boston, MA
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Adolescents, Persons with co-occurring mental and substance abuse disorders, Persons with HIV/AIDS, Pregnant/postpartum women, Women, Men, Criminal justice clients

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STEP Inc
(617) 720-0153
131 Beverly Street
Boston, MA
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Substance abuse
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Women, Men, Criminal justice clients
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ASL or other assistance for hearing impaired, Spanish

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Volunteers of America
(617) 262-7142
686 Massachusetts Avenue
Boston, MA
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Massachusetts General Hospital
(617) 726-2712
16 Blossom Street
Boston, MA
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Bridge Over Troubled Waters Inc
(617) 423-9575
47 West Street
Boston, MA
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Hope House Inc
(617) 267-4673
42 Upton Street and
Boston, MA
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Substance abuse , Halfway house
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Residential long-term treatment (more than 30 days)
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Spanish

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Victory Programs Inc
(617) 262-5032x15
566 Massachusetts Avenue
Boston, MA
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Substance abuse , Halfway house
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Residential long-term treatment (more than 30 days)
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Persons with co-occurring mental and substance abuse disorders, Persons with HIV/AIDS, Gays and Lesbians, Seniors/older adults, Men, Criminal justice clients
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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