Side Effects of Lidocaine Pelham AL

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Shelby County Treatment Center
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750 Highway 31 South
Alabaster, AL
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Alabama Abuse Counseling Center
(205) 428-2600
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Bessemer, AL
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Persons with co-occurring mental and substance abuse disorders, Women, Men, DUI/DWI offenders, Criminal justice clients

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Bradford Health Services
(800) 293-7191
631 Beacon Parkway West
Birmingham, AL
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Alcohol and Drug Abuse
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2701 Jefferson Avenue SW
Birmingham, AL
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Saint Annes Home Inc
(205) 933-2402
2772 Hanover Circle
Birmingham, AL
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Northwest Alabama Treatment Center
(205) 425-1200
4204 Edmonton Drive
Bessemer, AL
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University of Alabama at Birmingham
(205) 917-3784
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Birmingham, AL
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Birmingham Metro Treatment Center
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151 Industrial Drive
Birmingham, AL
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Fellowship House Inc
(205) 933-2430
1625 12th Avenue South
Birmingham, AL
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Department of Veterans Affairs
(205) 933-8101x6136
700 South 19th Street
Birmingham, AL
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Substance abuse
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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