Side Effects of Lidocaine Osawatonie KS

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Eagle Recovery Services
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5 South Peoria Street
Louisburg, KS
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2924 East Douglas Avenue
Wichita, KS
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Olathe, KS
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Addiction Stress Center
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1330 North 78th Street
Kansas City, KS
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Therapy Services
(620) 364-2606
420 Kennedy Street
Burlington, KS
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Elizabeth Layton Center Inc
(785) 242-3780
204 East 15th Street
Ottawa, KS
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Miracles Inc/Sanctuary House Program
(316) 303-9520
1738 North Market Street
Wichita, KS
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Elm Acres Youth and Family Service
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501 Central Avenue
Columbus, KS
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Mirror Inc
(620) 665-7750
2100 North Jackson Street
Hutchinson, KS
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Cowley County Mental Health and
(620) 442-4540
22214 D Street
Winfield, KS
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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