Side Effects of Lidocaine Loveland OH

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Bethesda Blue Ash Treatment Program
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Cincinnati, OH
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(513) 398-2551
201 Reading Road
Mason, OH
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Cincinnati Teen Challenge
(513) 248-0452x105
1466 U.S. Route 50
Milford, OH
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Norcen Behavioral Health Systems
(513) 761-6222
7162 Reading Road
Cincinnati, OH
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Mels Behavioral Health Services Inc
(513) 948-8119
7505 Reading Road
Cincinnati, OH
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4050 Executive Park Drive
Cincinnati, OH
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Pathway Family Center
(513) 575-7300
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Milford, OH
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Talbert House North Star
(513) 755-8133
9018 Cincinnati-Columbus Road
West Chester, OH
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Recovery Resource Center Inc
(513) 761-7353
7710 Reading Road
Cincinnati, OH
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Christ Hospital
(513) 585-8500
3200 Burnet Avenue
Cincinnati, OH
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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