Side Effects of Lidocaine Bristol RI

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Habit OPCO
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Stanley Street Treatment and Resources
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Fall River, MA
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Seven Hills Behavioral Health
(508) 679-0962x223
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Fall River, MA
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AdCare Hospital of Worcester Inc
(401) 732-1500
400 Bald Hill Road
Warwick, RI
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Kent House Inc
(401) 781-2700
2020 Elmwood Avenue
Warwick, RI
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Saint Anne''s Hospital
(508) 235-5010
795 Middle Street
Fall River, MA
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Family Services Association of
(508) 678-7542
151 Rock Street
Fall River, MA
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Steppingstone Inc
(508) 674-2788
542 North Main Street
Fall River, MA
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Kent Center
(401) 732-5656
2756 Post Road
Warwick, RI
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Persons with co-occurring mental and substance abuse disorders, Pregnant/postpartum women, Women, DUI/DWI offenders
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Addiction Recovery Institute
(401) 737-4788
205 Hallene Road
Warwick, RI
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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