Side Effects of Lidocaine Arnold MO

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Community Services of MO
(636) 282-2426
14 Fox Valley Street
Arnold, MO
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Community Services of MO
(314) 849-6855
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Saint Louis, MO
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Christian Hospital Recovery Centers
(314) 842-7220
11200 Tesson Ferry Street
Saint Louis, MO
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Harris House
(314) 631-4299
8327 South Broadway
Saint Louis, MO
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Preferred Family Healthcare Inc
(314) 961-6017
2945 South Brentwood Boulevard
Brentwood, MO
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COMTREA Inc
(636) 296-6206x118
21 Municipal Drive
Arnold, MO
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Assessment and Counseling Solutions
(314) 849-2800
4400 South Lindbergh Boulevard
Saint Louis, MO
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Provident Inc
(314) 898-0101
6555 Chippewa
Saint Louis, MO
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Community Services of MO
(314) 984-9210
11736 Manchester Road
Des Peres, MO
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Outpatient
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Human Support Services
(618) 939-4444
988 North Illinois Route 3
Waterloo, IL
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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