Side Effects of Lidocaine Apollo PA

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

RHJ Medical Center Inc
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Vandergrift, PA
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408 8th Street
New Kensington, PA
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Gateway/Monroeville
(412) 373-2234
4327 Northern Pike
Monroeville, PA
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Substance abuse
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Adolescents
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Turtle Creek Valley MH/MR Inc
(412) 824-9300x692
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Turtle Creek, PA
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Substance abuse
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Persons with co-occurring mental and substance abuse disorders, Criminal justice clients

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Greenbriar Treatment Center
(724) 339-7180
601 6th Street
New Kensington, PA
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Substance abuse
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Butler Regional Recovery Program
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1301 Carlisle Street
Natrona Heights, PA
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Family Services Of Western Pennsylvani
(724) 226-0664x833
321 East 5th Avenue
Tarentum, PA
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Teen Challenge of Western Pennsylvania
(724) 265-4100
220 Challenge Lane
Rural Ridge, PA
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Substance abuse
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Gateway
(412) 963-7077
1360 Old Freeport Road
Pittsburgh, PA
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Substance abuse
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Outpatient, Partial hospitalization/day treatment
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Adolescents
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Side Effects of Lidocaine

INTRODUCTION TO LIDOCAINE

Lidocaine is a substance administered intravenous in the treatment of ventricular arrhythmias, is generally very well tolerated. The major side effects primarily involve the central nervous system, the cardiovascular system, and the gastrointestinal tract.

LIDOCAINE NEUROLOGIC TOXICITY

The most common adverse effect of lidocaine is central nervous system (CNS) toxicity. The symptoms are usually mild, dose-dependent, and always resolve with a decrease in the infusion rate or discontinuation of the drug. These side effects may be particularly frequent in the elderly or in those with heart failure, settings in which CNS levels are increased due to a reduced volume of distribution, and in patients with significant liver impairment in whom the metabolism of lidocaine is reduced.

Tremor is a useful bedside sign of toxicity. Other neurologic side effects include insomnia or drowsiness, lightheadedness, dysarthria and slurred speech, ataxia, depression, agitation, change in sensorium, a change in personality, nystagmus, hallucinations, memory impairment, and emotional lability.

High plasma concentrations of lidocaine can also provoke seizures that are usually generalized. This can also occur at lower drug concentrations if lidocaine is given to patients receiving oral tocainide or mexiletine, which are congeners of lidocaine.

LIDOCAINE CARDIOVASCULAR TOXICITY

Cardiac side effects are an infrequent complication of lidocaine therapy which is general...

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